Predicted Winner in BOLD
Arthur Ashe Stadium (Noon start)
 Serena Williams (USA) vs.  Sloane Stephens (USA) – This is really hard to pick and on paper I think Serena wins, but my gut says the COVID-19 break helped Sloane Stephens hit reset.
 Madison Keys (USA) vs Alizé Cornet (FRA) – Cornet is one of the most difficult players to eliminate at majors, but I think if Keys keeps her mental game in order she wins in 2 close sets.
Louis Armstrong Stadium (11 a.m. start)
 Maria Sakkari (GRE) vs  Amanda Anisimova (USA) – Νικητής
Victoria Azarenka (BLR) vs. Iga Swiatek (POL) – Vika rising!
 Sofia Kenin (USA) vs.  Ons Jabeur (TUN)
 Donna Vekic (CRO) vs [PR] Tsvetana Pironkova (BUL) – This is a 50-50 match.
 Elise Mertens (BEL) vs Caty McNally (USA)
 Karolina Muchova (CZE) vs Sorana Cirstea (ROU) – Cirstea’s streak continues?