Arthur Ashe Stadium
 Novak Djokovic (SRB) vs.  Pablo Carreño Busta (ESP) – Novak in 3 or 4 sets seems really likely.
 David Goffin (BEL) vs.  Denis Shapovalov (CAN) – I like Goffin here, but Denis could pull the minor upset. I think Goffin will rob his opponent of enough time to win in 4 or 5 sets.
Louis Armstrong Stadium
 Alexander Zverev (GER) vs. Alejandro Davidovich Fokina (ESP) – Zverev should win.
 Borna Coric (CRO) vs. Jordan Thompson (AUS) – Coric should win despite back-to-back 5 sets wins including a ridiculous comeback involving saving 6 match points.