Predicted Winners in BOLD
 Simona Halep (ROU) vs  Timea Babos (HUN) – Halep should win, but she will need to hold her court positioning.
 Serena Williams (USA) vs. Johanna Larsson (SWE) – This has the feel of a trap match, but I think Serena will advance in two sets with one set being a bit too close for comfort.
 Venus Williams (USA) vs  Laura Siegemund (GER) – Again Venus has earned the benefit of the doubt.
 Carla Suarez Navarro (ESP) vs  Elena Vesnina (RUS) – This is a 50-50 match, but I think Vesnina strong summer will continue.
 Agnieszka Radwanska (POL) vs  Caroline Garcia (FRA) – This certainly could go to Aga, but I have a feeling Garcia has the goods today.
[Q] Ana Konjuh (CRO) vs. Varvara Lepchenko (USA) – What a chance for each player to pile up ranking points.
 Karolina Pliskova (CZE) vs  Anastasia Pavlyuchenkova (RUS) – Pliskova was impressive in winning Cincinnati and has a workable path to go deep in New York.
Yaroslava Shvedova (KAZ) vs. Shuai Zhang (CHN) – This match is another great opportunity for each player.