Predicted Winner in BOLD
 Rafael Nadal (ESP) vs. Leonardo Mayer (ARG) – Mayer is a rugged player who will try to test Rafa, but an upset here would be stunning.
 Grigor Dimitrov (BUL) vs. [Q] Mackenzie McDonald (USA) – Dimitrov has to believe in himself a lot more than he did in year’s past due to his form in Oz last year along with his 2017 World Tour Finals and Cincinnati titles.
 Jo-Wilfried Tsonga (FRA) vs. Denis Shapovalov (CAN) – Generational turning?
Alexandr Dolgopolov (UKR) vs. Matthew Ebden (AUS) – The Dolg could do it or could play terribly.
 Marin Cilic (CRO) vs. Joao Sousa (POR) – I will go with a mild upset here. Cilic should love the conditions in Australia and had a big run in 2010, but I am not convinced as of yet that he is a contender in 2018.
 Nick Kyrgios (AUS) vs. Viktor Troicki (SRB) – Nick Kyrgios could use a big Aussie Open.
 Gilles Muller (LUX) vs. Malek Jaziri (TUN) – This should be a fun match.
 Andrey Rublev (RUS) vs. Marcos Baghdatis (CYP) – Baghdatis could turn back the clock to 2006, but the odds are against it
 Pablo Carreño Busta (ESP) vs. Gilles Simon (FRA) – A risky pick, but Simon seems to be dialed in in recent weeks.
 Damir Dzumhur (BIH) vs. John Millman (AUS) – I’ve gone upset crazy.
 Pablo Cuevas (URU) vs. Ryan Harrison (USA) – Harrison is one of the few remaining US men. I think he could win, but Cuevas is the overdog here.
 Diego Schwartzman (ARG) vs. [Q] Casper Ruud (NOR) – The qualifier will have a shot, but at what point does match tough turn into leg weary?
Yoshihito Nishioka (JPN) vs. Andreas Seppi (ITA) – Prego
Ivo Karlovic (CRO) vs. Yuichi Sugita (JPN) – Karlovic has been on tour a long time, but his style of play is not overly rough on the body. Karlovic at 45 can be my doubles partner any day, but at 38 he is still pretty young.
Kyle Edmund (GBR) vs. Denis Istomin (UZB) – Giant killers collide?
Nikoloz Basilashvili (GEO) vs. [Q] Ruben Bemelmans (BEL) – Georgia has had a rough 52 weeks in championships, but that is a different Georgia.