Predicted Winners in BOLD
Rod Laver Arena (11 a.m. start)
 Karolina Pliskova (CZE) vs.  Karolina Muchova (CZE) – The fast courts should help Pliskova advance.
 Belinda Bencic (SUI) vs.  Elise Mertens (BEL)
 Anett Kontaveit (EST) vs. Shelby Rogers (USA)
Margaret Court Arena
 Elina Svitolina (UKR) vs.  Yulia Putintseva (KAZ) – This should be a 3 set thriller.
 Donna Vekic (CRO) vs. Kaia Kanepi (EST) – Kanepi can keep advancing. This one likely goes 3 sets.
 Ashleigh Barty (AUS) vs.  Ekaterina Alexandrova (RUS) – This should be a good match.
John Cain Arena (Noon start)
Jessica Pegula (USA) vs. Kristina Mladenovic (FRA) – Why not keep the good times rolling?
 Jennifer Brady (USA) vs. [Q] Kaja Juvan (SLO)