Predicted Winners in BOLD
Rod Laver Arena (11 a.m. start)
 Daniil Medvedev (RUS) vs.  Filip Krajinovic (SRB)
 Rafael Nadal (ESP) vs. Cameron Norrie (GBR) – Rafa and Daniil ought to advance.
Margaret Court Arena
 Andrey Rublev (RUS) vs. Feliciano Lopez (ESP) – Rublev will need to return well and pass when Lopez comes forward. I think he does that well enough to win in 4 good sets.
 Fabio Fognini (ITA) vs.  Alex de Monaur (ESP) – I like Fognini to advance.
John Cain Arena (Noon start)
 Stefanos Tsitsipas (GRE) vs. Mikael Ymer (SWE) – Ymer has had a great run and Tsitsipas might be leg weary from his 2nd round battle. Still, Tsitsipas should advance.
 Matteo Berrettini (ITA) vs.  Karen Khachanov (RUS) – The winner of this match might move into dark horse status.
 Casper Ruud (NOR) vs. Radu Albot (MDA)
Mackenzie McDonald (USA) vs. Lloyd Harris (RSA) – Someone is moving forward to a lot of computer points.