Predicted Winners in BOLD
Rod Laver Arena
 Dominic Thiem (AUT) vs.  Grigor Dimitrov (BUL) – This should be an outstanding match. I think Thiem is younger, moves better, and has the better forehand of the two. I expect a 3 to 4 set win for Thiem, but Dimitrov has a shot at the upset.
 Novak Djokovic (SRB) vs.  Milos Raonic (CAN) – Raonic is playing well. Still, Novak has 8 Australian Open titles, 17 majors, and is the world #1 for a reason. I am think Novak Djokovic wins in 4 sets.
Margaret Court Arena
 Félix Auger-Aliassime (CAN) vs. [Q] Aslan Karatsev (RUS) – FA-A has a wonderful chance to reach the quarterfinal round and set a foundation for a great 2021 season.
 Alexander Zverev (GER) vs.  Dusan Lajovic (SRB)