Arthur Ashe Stadium (11 a.m. start)
 Rafael Nadal (ESP) vs  Lucas Pouille (FRA) – I like Rafa to win and likely in straight sets. I could see Pouille making one set close or even stealing a set.
 Novak Djokovic (SRB) vs. Kyle Edmund (GBR) – Novak needs to get into the flow of the tournament with a solid outing here. I think he wins, but his arm will be under a lot of scrutiny.
Louis Armstrong Stadium
 Jo-Wilfried Tsonga (FRA) vs  Jack Sock (USA) – I have picked against Sock the last two rounds and looked foolish. I think Tsonga is the better player, but Sock is playing well and has that forehand.
— ATP World Tour (@ATPWorldTour) September 1, 2016
 Gael Monfils (FRA) vs. Marcos Baghdatis (CYP) – If Monfils has recovered from his late match scare, he should find a way past a resurgent Baghdatis. Both men have had good 2016 seasons, but Gael is in better overall form and has more upside in this match.