Predicted winners in BOLD
Rod Laver Arena (11 a.m. start)
 Novak Djokovic (SRB) vs. Frances Tiafoe (USA) – Tiafoe could push a set to a tiebreak. That means this could go 4, but Novak should win with little reason for concern.
 Alexander Zverev (GER) vs. [Q] Maxime Cressy (USA)
Margaret Court Arena (Both seeded one-handers should advance)
 Dominic Thiem (AUT) vs. Dominik Koepfer (GER)
 Grigor Dimitrov (BUL) vs. [WC] Alex Bolt (AUS)
John Cain Arena
 Stan Wawrinka (SUI) vs. Marton Fucsovics (HUN) – A conflagration with Novak is looming.
 Ugo Humbert (FRA) vs. Nick Kyrgios (AUS)
 Diego Schwartzman (ARG) vs. [LL] Alexandre Muller (FRA)
 Taylor Fritz (USA) vs. Reilly Opelka (USA)
Court 3 – Canada on the Rise?
 Félix Auger-Aliassime (CAN) vs. James Duckworth (USA)
 Denis Shapovalov (CAN) vs. [Q] Bernard Tomic (AUS)
 Milos Raonic (CAN) vs. Corentin Moutet (FRA) – See above
 Pablo Carreño Busta (ESP) vs. Jiri Vesely (CZE)
 Dusan Lajovic (SRB) vs. Alexander Bublik (KAZ)
 Adrian Mannarino (FRA) vs. Miomir Kecmanovic (SRB)
Emil Ruusuvuori (FIN) vs. Pedro Martinez (ESP) – The Spanish Armada is in the Pacific
Egor Gerasimov (BLR) vs. [Q] Aslan Karatsev (RUS) – Heavy legs from qualifying?