Predicted winners in BOLD

Rod Laver Arena (11 a.m. start)

[1] Novak Djokovic (SRB) vs. Frances Tiafoe (USA) – Tiafoe could push a set to a tiebreak. That means this could go 4, but Novak should win with little reason for concern.
[6] Alexander Zverev (GER) vs. [Q] Maxime Cressy (USA) 

Margaret Court Arena (Both seeded one-handers should advance)

[3] Dominic Thiem (AUT) vs. Dominik Koepfer (GER)
[18] Grigor Dimitrov (BUL) vs. [WC] Alex Bolt (AUS) 

John Cain Arena

[17] Stan Wawrinka (SUI) vs. Marton Fucsovics (HUN) – A conflagration with Novak is looming.
[29] Ugo Humbert (FRA) vs. Nick Kyrgios (AUS)

1573 Arena

[8] Diego Schwartzman (ARG) vs. [LL] Alexandre Muller (FRA)
[27] Taylor Fritz (USA) vs. Reilly Opelka (USA)

Court 3 – Canada on the Rise?

[20] Félix Auger-Aliassime (CAN) vs. James Duckworth (USA)
[11] Denis Shapovalov (CAN) vs. [Q] Bernard Tomic (AUS) 

Court 7

[14] Milos Raonic (CAN) vs. Corentin Moutet (FRA) – See above
[15] Pablo Carreño Busta (ESP) vs. Jiri Vesely (CZE) 

Court 8

[23] Dusan Lajovic (SRB) vs. Alexander Bublik (KAZ)
[32] Adrian Mannarino (FRA) vs. Miomir Kecmanovic (SRB)

Court 13

Emil Ruusuvuori (FIN) vs. Pedro Martinez (ESP) – The Spanish Armada is in the Pacific

Court 17

Egor Gerasimov (BLR) vs. [Q] Aslan Karatsev (RUS) – Heavy legs from qualifying?