Predicted Winners in BOLD
Rod Laver Arena (11 a.m. start)
 Alexander Zverev (GER) vs.  Adrian Mannarino (FRA) – This probably won’t happen, but my gut feeling says upset.
 Novak Djokovic (SRB) vs.  Taylor Fritz (USA) – Fritz has had a nice event. Novak will advance.
Margaret Court Arena
 Pablo Carreño Busta (ESP) vs.  Grigor Dimitrov (BUL) – PCB would benefit from slower conditions.
 Denis Shapovalov (CAN) vs.  Félix Auger-Aliassime (CAN) – The dynamics of their friendship plus Shapovalov sometimes having clunky matches make this hard to predict. If they both play reasonably well, I think Denis wins at this stage of their careers.
John Cain Arena (Noon start)
 Diego Schwartzman (ARG) vs. [Q] Aslan Karatsev (RUS) – Diego is the wrong opponent for a potentially leg weary qualifier.
 Dominic Thiem (AUT) vs. Nick Kyrgios (AUS) – Kyrgios has a puncher’s chance, but unless he can exploit Thiam surrendering real estate by returning from very deep, I don’t think Thiem has to worry.
 Milos Raonic (CAN) vs Marton Fucsovics (HUN) – We should not forget that Raonic was close to an Australian Open final in 2016.
 Dusan Lajovic (SRB) vs. Pedro Martinez (ESP)